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 Application Notes

 Overview

Static Headspace analysis is a time-tested and robust technique for the analysis of volatile compounds in almost any matrix. The popularity of the technique is due to Headspace analysis providing a clean, reliable result.

Teledyne Tekmar draws on our experience as a leader in low-level VOC analysis with the introduction of a next generation Headspace instrument, the HT3™ Static and Dynamic Headspace System.

Dramatic improvements in sensitivity are achieved with the new Dynamic Headspace option, while maintaining the ruggedness and reliability of a traditional Static Headspace instrument.​

Applications and Industries 

VOC sampling and analysis are used in a wide range of applications in the following industries:

  • Pharmaceutical 
    • Residual Solvents
    • Impurities from drug substances 
    • Impurities from container closure systems 
  • Flavor, Fragrance, and Packaging
  • Petrochemical
  • Blood Alcohol and Forensic Toxicology 
  • Polymers
  • Environmental

Methods 

  • USP <467> (See applications above.) 
  • EPA Method 5021 
  • RSK-175​

 Key Features

  • Standard integrated 60-position autosampler with 10-position platen heater provides true walk away automation

  • Increased sensitivity from 50 to 100 times with the Dynamic Headspace option (compound dependent)

  • Removable sample path for trouble-free maintenance 

  • High temperature capability to 300 °C expands range of applications

  • Inert sample pathway including transfer line, sample needle and loop provide superior analytical results by eliminating adsorption and reducing carryover 

  • Automated Leak Check and Benchmark for quick troubleshooting

  • Automated method development using Method Optimization Mode (M.O.M.)

  • 21 CFR Compliance

  • Built-in Mass Flow Controller ensures consistent flow and pressure for all samples regardless of external conditions​

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