A Guide for Analyzing Low-Level Total Organic Carbon Using a UV/ Persulfate Analyzer

Total Organic Carbon (TOC) analysis is a fast and efficient analytical technique that can be easily implemented in pharmaceutical manufacturing for cleaning validation due to the all-inclusive nature of the test for carbon. It can be used to test for residues of previously manufactured products, cleaning detergents, solvents, by-products, and degradants. Although the current requirement set by the pharmacopeias for instrument performance is at 500 parts per billion (ppb), many pharmaceutical companies regularly test at one-tenth and even one-hundredth that requirement. This application note discusses guidelines for performing low-level TOC analysis using a UV/ Persulfate analyzer.

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